News

We warmly welcome Filip Bergquist as a new Board member. He will be replacing Gesine Paul-Visse as SWEMODIS representative.

You can read more about Filip on the board page.

We hope you aren’t missing out on our awesome archive of webinar lectures. We wish to provide you with valuable insights and knowledge, and the latest from the fascinating world of the basal ganglia.

But we want to hear from you, too! Please let us know what more you would like to hear about or the specific researchers and experts you’d like to hear from. Your input helps us tailor our future content to your interests and needs.

Here’s a taste of what our archive has to offer:

Title:	Presenter:
A single-cell perspective on human dopaminergic neurons in the developing and adult midbrain	Ernest Arenas
Adaptive DBS – are  we ready for clinical application?	Andrea Kuhn
Alcohol Shifts the Balance Between Associative and Sensorimotor Cortico-Thalamo-Basal Ganglia Circuit Control of Behavior	David M Lovinger
Altered striatal dopamine in tardive dyskinesia	Alexandra Nelson
Axonal gating of striatal dopamine transmission by neuronal and non-neuronal networks	Stephanie Cragg
Bayesian mapping of the striatal microcircuit	Mark Humphries
Behavioural and neurophysiological transformations elicited by nicotine	Louise Adermark
Cell-type specific auditory responses in the auditory striatum are driven by feed forward inhibition	Tanya Sippy
Circuit-Based Strategies For Long-Lasting Motor Recovery Following Dopamine Depletion	Aryn H. Gittis
Clinical studies on serotonin mechanisms in L-dopa-induced dyskinesias	Per Svenningsson
Computational models of basal ganglia physiology: dopamine, beta oscillations, and nigrothalamic transmission	Robert Schmitt
Cortico-basal ganglia connections: a across species-approach for understanding and probing circuits in the human brain	Suzanne Haber
Data-driven simulations of basal ganglia microcircuits	Jeanette Hellgren-Kotaleski
Developing a novel chemogenetic strategy for opiod use disorder	Lucas L. Sjulson
Disinhibitory gating of discrimination learning and spine enlargement by dopamine D2 receptors in the nucleus accumbens	Sho Yagishita
Disruption of mitochondrial complex I induced progressive parkinsonism with nigral determinants	James Surmeier
Distinct cortico- and thalamo-striatal plasticity subtends distinct learning strategies	Laurent Venance
Diversity of Midbrain Dopamine Neurons	Rajeshwar Awatramani
Dopamine and acetylcholine: enigmantic modulators of the striatum.	Jeff Wickens
Dopamine Dynamics for Learning and Motivation	Joshua Berke
Dopamine neurons and reward	Wolfram Schultz
Dopamine waves as a mechanism for spatiotemporal credit assignment	Arif Hamid
Encoding and updating action-outcome associations in the striatum and affiliated circuits	Bernard Balleine
Feedforward and feedback interactions in the triatum	Arvind Kumar
GPCR hetorecomplexes in the brain and their reorganization increases our understanding of Parkinson’s disease	Kjell Fuxe
In search of a unifying function of the dorsal striatum…a simple question of effort?	David Robbe
Instrinsic dopamine and acetylcholine dynamics in the striatum of mice	Nicolas Tritch
Interrogating dopamine neuron development at the single cell level	Thomas Perlmann
Learning from Dysfunction: A view from the globus pallidus	Nicolas Mallet
Liking’ as shaping; ‘wanting’ as reinforcing	Peter Dayan
Linking brainstem locomotor command pathways to restoration of motor function in Parkinsonism	Ole Kiehn
Making sense of dopaminergic heterogeneity	Ilana Witten
Mapping from basal ganglia dynamics to decision policies	Jonathan E. Rubin
Mapping the organization and function of brain circuits	Dinos Meletis
Midbrain circuits regulating motor gating	Juan Mena Segovia
Motor learning regulator? Significance of proteostasis pathway activity in striatal cholinergic interneurons.	Nicole Calakos
Neurons to Network in the Globus Pallidus	Charles Wilson
Possible roles of alpha-synuclein in the pathogenesis of basl ganglia discorder	Patrik Brundin
Possible roles of the basal ganglia in control and inference	Kenji Doya
Sensory transmission in corticostriatal networks	Ramón Reig García
Sentitized dopamine transmission in the parkinsonian brain	Gilberto Fisone
Stem cell therapy for Parkinson´s disease: From cell replacement to circuitry repair	Anders Björklund
Stimulating at the right time	Hayriye Cagnan
Striatal pathways and dopamine receptors in L-DOPA-induced dyskinesia	Angela Cenci Nilsson
Synaptic Connectivity in the Striatal Orchestra	Gilad Silberberg
The coming of age of the basal ganglia	Ann Graybiel
The involvement of cortico-basal ganglia circuits in spontaneous and learned behaviors	Per Petersson
The neuroscientist’s guide to schizophrenia: a data-driven prioritization of circuits	Jens Hjerling Leffler
The role of basal ganglia input to the ventromedial thalamus in motor decision making and timing	Dieter Jaeger
The role of the basal ganglia in motor skill learning and execution	Bence P Ölveczky
To sleep or not to sleep in Parkinson’s disease and DBS procedure?	Hagai Bergman
Traveling waves of acetylcholine and dopamine release in the striatum	Josh Goldberg
Upregulation of D1 receptor signaling biases toward punishment-resistant alcohol drinking	Veronica Alvarez
What does basal ganglia activity teach us about the pathophysiology of movement disorders?	Atsushi Nambu
With the basal ganglia over 500 million years – function and intrinsic networks	Sten Grillner
ZSwim6: A window into mechanisms of disease-associated striatal dysfunction	Marc Fuccillo

Dive into our archive, and let us know your thoughts and suggestions. We look forward to hearing from you and continuing to provide valuable content for your interests.

All Members are welcome to our annual meeting scheduled for November 24 at 15:00-15:30 CET.
Please find the agenda here: https://swebags.ebrains.se/forums/topic/annual-meeting-2023/

New recordings from the latest webinar are now available in the webinar archive:

Dopamine waves as a mechanism for spatiotemporal credit assignment with Arif Hamid

Traveling waves of acetylcholine and dopamine release in the striatum with Josh Goldberg

Author: Espa E, Song L, Skovgård K, Fanni S, Cenci MA.

Abstract:

Background: Current models of L-DOPA-induced dyskinesia (LID) are obtained by treating dopamine-depleted animals with L-DOPA. However, patients with LID receive combination therapies that often include dopamine agonists. 

Objective: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of LID-related neuroplasticity and drug responses. 

Methods: Different regimens of L-DOPA monotreatment and L-DOPA-ropinirole cotreatment were compared using measures of hypokinesia and dyskinesia. Striatal expression of ∆FosB and angiogenesis markers were studied immunohistochemically. Antidyskinetic effects of different drug categories were investigated in parallel groups of rats receiving either L-DOPA monotreatment or L-DOPA combined with ropinirole.

Results: We defined chronic regimens of L-DOPA monotreatment and L-DOPA-ropinirole cotreatment inducing overall similar abnormal involuntary movement scores. Compared to the monotreatment group, animals receiving the L-DOPA-ropinirole combination exhibited an overall lower striatal expression of ∆FosB with a distinctive compartmental distribution. The expression of angiogenesis markers and blood-brain barrier hyperpermeability was markedly reduced following L-DOPA-ropinirole cotreatment vs L-DOPA monotreatment. Significant group differences were moreover detected upon comparing the response to candidate antidyskinetic drugs. In particular, compounds modulating D1 receptor signaling had a stronger effect in the L-DOPA-only group, whereas both amantadine and the selective NMDA antagonist MK801 produced a markedly larger antidyskinetic effect in L-DOPA-ropinirole cotreated animals.

Conclusions: Cotreatment with ropinirole altered LID-related neuroplasticity and pharmacological response profiles. The impact of adjuvant dopamine agonist treatment should be taken into consideration when investigating LID mechanisms candidate interventions in both clinical and experimental settings. 

Link: https://pubmed.ncbi.nlm.nih.gov/36656044/

The abstract submission deadline and early-bird registration time has been prolonged to January 31st 2023.