Decoding subthalamic neurocircuitry in motion and emotion – vacant PhD position!

Vacant PhD position in Neurobiology – Neurocircuitry analysis at Uppsala University.
Look at this link for information and how to apply:
Deadline May 20.
Please use the Varbi system to submit your application, as specified.
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New publication: Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice

Authors: Adriane Guillaumina, Gian Pietro Serra, François Georges, Åsa Wallén-Mackenzie

illustration of experimentation

The subthalamic nucleus (STN) is critical for the execution of intended movements. Loss of its normal function is strongly associated with several movement disorders, including Parkinson’s disease for which the STN is an important target area in deep brain stimulation (DBS) therapy. Classical basal ganglia models postulate that two parallel pathways, the direct and indirect pathways, exert opposing control over movement, with the STN acting within the indirect pathway. The STN is regulated by both inhibitory and excitatory input, and is itself excitatory. While most functional knowledge of this clinically relevant brain structure has been gained from pathological conditions and models, primarily parkinsonian, experimental evidence for its role in normal motor control has remained more sparse. The objective here was to tease out the selective impact of the STN on several motor parameters required to achieve intended movement, including locomotion, balance and motor coordination. Optogenetic excitation and inhibition using both bilateral and unilateral stimulations of the STN were implemented in freely-moving mice. The results demonstrate that selective optogenetic inhibition of the STN enhances locomotion while its excitation reduces locomotion. These findings lend experimental support to basal ganglia models of the STN in terms of locomotion. In addition, optogenetic excitation in freely-exploring mice induced self-grooming, disturbed gait and a jumping/escaping behavior, while causing reduced motor coordination in advanced motor tasks, independent of grooming and jumping. This study contributes experimentally validated evidence for a regulatory role of the STN in several aspects of motor control.

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Inauguration of SWEBAGS

illustration of newletter for inauguration

Join us at the inauguration the 22nd of January when Anders Björklund and Sten Grillner will give their honorary lectures.

15:00 Opening and Welcome
15:20 Honorary lecture: Anders Björklund, Senior Professor, Lund University
16:00 Honorary lecture: Sten Grillner, Senior Professor, Karolinska Institute
16:40 Discussion

Event page

Inauguration Poster

Angela Cenci Nilsson appointed as the Coordinator of Multipark

Logo of Multipark Lund

Angela Cenci Nilsson has been appointed to coordinate Multipark (Multidisciplinary research focused on Parkinson´s disease) for the next 3 years (2021-2023). Multipark is a strategic research environment supported by the Swedish Government and hosted by Lund University. Its vast programme ranges from fundamental investigations into disease mechanisms to studies on the life situation of patients affected by Parkinson’s and other neurodegenerative disorders. As a research area of excellence, Multipark has the dual mission of creating a vibrant scientific environment and benefitting society at large (which is achieved by developing innovations and new treatments for neurodegenerative diseases).

Founding of SWEBAGS

profile picture of the board members

Today the 26th of November 2020 SWEBAGS was officially formed and the first board was elected. Together the board members represent a wide range of expertise and different research approaches. We look forward to working together for SWEBAGS!

Please join us by becoming a member!